05 Jan 2013

 Other Names:
5'-methyltetrahydrofolate, 5'-MTHF, Acide Folique, Acide Ptéroylglutamique, Acide Ptéroylmonoglutamique, Acido Folico, B Complex Vitamin, Complexe de Vitamines B, Complexe Vitaminique B, Dihydrofolate, Folacin, Folacine, Folate, 

Folinic Acid, L-methylfolate, Methylfolate, Méthylfolate, Pteroylglutamic Acid, Pteroylmonoglutamic Acid, Pteroylpolyglutamate, Tetrahydrofolate, Tétrahydrofolate, Vitamin B9, Vitamine B9.

Over views

Folate and folic acid are forms of a water-soluble B vitamin. Folate occurs naturally in food, and folic acid is the synthetic form of this vitamin. Since 1998, folic acid has been added to cold cereals, flour, breads, pasta, bakery items, cookies, and crackers, as required by federal law. Foods that are naturally high in folate include leafy vegetables (such as spinach, broccoli, and lettuce), okra, asparagus, fruits (such as bananas, melons, and lemons) beans, yeast, mushrooms, meat (such as beef liver and kidney), orange juice, and tomato juice.
Folic acid is used for preventing and treating low blood levels of folate (folate deficiency), as well as its complications, including “tired blood” (anemia) and the inability of the bowel to absorb nutrients properly. Folic acid is also used for other conditions commonly associated with folate deficiency, including ulcerative colitis, liver disease, alcoholism, and kidney dialysis.
Women who are pregnant or might become pregnant take folic acid to prevent miscarriage and “neural tube defects,” birth defects such as spina bifida that occur when the fetus’s spine and back do not close during development.
Some people use folic acid to prevent colon cancer or cervical cancer. It is also used to prevent heart disease and stroke, as well as to reduce blood levels of a chemical called homocysteine. High homocysteine levels might be a risk for heart disease.
Folic acid is used for memory loss, Alzheimer’s disease, age-related hearing loss, preventing the eye disease age-related macular degeneration (AMD), reducing signs of aging, weak bones (osteoporosis), jumpy legs (restless leg syndrome), sleep problems, depression, nerve pain, muscle pain, AIDS, a skin disease called vitiligo, and an inherited disease called Fragile-X syndrome. It is also used for reducing harmful side effects of treatment with the medications lometrexol and methotrexate.
Some people apply folic acid directly to the gum for treating gum infections.
Folic acid is often used in combination with other B vitamins.

How does it work?

Folic acid is needed for the proper development of the human body. It is involved in producing the genetic material called DNA and in numerous other bodily functions.

Likely Effective for:
  Kidney disease. About 85% of people with serious kidney disease have high levels of homocysteine. High levels of homocysteine have been linked to heart disease and stroke. Taking folic acid lowers homocysteine levels in people with serious kidney disease. However, folic acid supplementation does not appear to reduce the risk of heart disease-related events.
 High amounts of homocysteine in the blood (hyperhomocysteinemia). High levels of homocysteine have been linked to heart disease and stroke. Taking folic acid lowers homocysteine levels by 20% to 30% in people with normal to slightly elevated homocysteine levels. It is recommended that people with homocysteine levels greater than 11 micromoles/L supplement with folic acid and vitamin B12.
 Reducing harmful effects of a medicine called methotrexate. Taking folic acid seems to reduce nausea and vomiting, which are possible side effects of methotrexate treatment.

 Birth defects (neural tube defects). Consuming high amounts of folate in the diet and taking folic acid supplements during pregnancy reduces the risk of neural tube birth defects.

Possibly Effective for :
    Age-related vision loss (age-related macular degeneration). Some research shows that taking folic acid with other vitamins including vitamin B6 and vitamin B12 reduces the risk of developing age-related vision loss.
    Depression. Limited research suggests that taking folic acid along with antidepressants seems to improve symptoms in people with depression.
    High blood pressure. Research suggests that taking folic acid daily for at least 6 weeks reduces blood pressure in people with high blood pressure. However, taking folic acid with blood pressure medication does not seem to lower blood pressure any more than taking just the medication alone.
    Gum problems due to a drug called phenytoin. Applying folic acid to the gums seems to prevent gum problems caused by phenytoin. However, taking folic acid by mouth does not seem to improve symptoms of this condition.
    Gum disease during pregnancy. Applying folic acid to the gums seems to improve gum disease during pregnancy.
    A skin discoloration disorder called vitiligo. Taking folic acid by mouth seems to improve symptoms of vitiligo.

Side effect 

Folic acid is LIKELY SAFE for most people when taken by mouth or injected into the body. Most adults do not experience any side effects when used in doses less than 1000 mcg daily.
Folic acid is POSSIBLY UNSAFE when taken by mouth in large doses, long-term. High doses of folic acid might cause abdominal cramps, diarrhea, rash, sleep disorders, irritability, confusion, nausea, stomach upset, behavior changes, skin reactions, seizures, gas, excitability, and other side effects.
There is some concern that taking too much folic acid for a long period of time might cause serious side effects. Some research suggests that taking folic acid in doses of 800-1200 mcg might increase the risk of heart attack in people who have heart problems. Other research suggests that taking these high doses might also increase the risk of cancer such as lung or prostate cancer.

Special Precautions & Warnings:
Pregnancy and breast-feeding: Folic acid is LIKELY SAFE when taken by mouth appropriately during pregnancy and breast-feeing. Taking 300-400 mcg of folic acid daily is commonly used during pregnancy to prevent birth defects.
Procedures to widen narrowed arteries (angioplasty): Using folic acid, vitamin B6, and vitamin B12 intravenously (by IV) or by mouth might worsen narrowed arteries. Folic acid should not be used by people recovering from this procedure.

Cancer: Early research suggests that taking 800-1000 mcg of folic acid daily might increase the risk of cancer. Until more is known, people with a history of cancer should avoid high doses of folic acid.

Heart disease: Early research suggests that taking folic acid plus vitamin B6 might increase the risk for heart attack in people with a history of heart disease.

Anemia caused by vitamin B12 deficiency: Taking folic acid might mask anemia caused by vitamin B12 deficiency and delay appropriate treatment.

Seizure disorder: Taking folic acid supplements might make seizures worse in people with seizure disorders, particularly in high doses.

Drug Interactions

    Fosphenytoin (Cerebyx) interacts with FOLIC ACID

    Fosphenytoin (Cerebyx) is used for seizures. The body breaks down fosphenytoin (Cerebyx) to get rid of it. Folic acid can increase how quickly the body breaks down fosphenytoin (Cerebyx). Taking folic acid along with fosphenytoin (Cerebyx) might decrease the effectiveness of fosphenytoin (Cerebyx) for preventing seizures.
    Methotrexate (MTX, Rheumatrex) interacts with FOLIC ACID

    Methotrexate (MTX, Rheumatrex) works by decreasing the effects of folic acid in the body's cells. Taking folic acid pills along with methotrexate might decrease the effectiveness of methotrexate (MTX, Rheumatrex).
    Phenobarbital (Luminal) interacts with FOLIC ACID

    Phenobarbital (Luminal) is used for seizures. Taking folic acid can decrease how well phenobarbital (Luminal) works for preventing seizures.
    Phenytoin (Dilantin) interacts with FOLIC ACID

    The body breaks down phenytoin (Dilantin) to get rid of it. Folic acid might increase how quickly the body breaks down phenytoin (Dilantin). Taking folic acid and taking phenytoin (Dilantin) might decrease the effectiveness of phenytoin (Dilantin) and increase the possibility of seizures.
    Primidone (Mysoline) interacts with FOLIC ACID

    Primidone (Mysoline) is used for seizures. Folic acid might cause seizure in some people. Taking folic acid can along with primidone (Mysoline) might decrease how well primidone works for preventing seizures.
    Pyrimethamine (Daraprim) interacts with FOLIC ACID

    Pyrimethamine (Daraprim) is used to treat parasite infections. Folic acid might decrease the effectiveness of pyrimethamine (Daraprim) for treating parasite infections.



    For folic acid deficiency: the typical dose is 250-1000 mcg (micrograms) per day.
    For preventing neural tube defects: at least 400 mcg of folic acid per day from supplements or fortified food should be taken by women capable of becoming pregnant and continued through the first month of pregnancy. Women with a history of previous pregnancy complicated by such neural tube defects usually take 4 mg per day beginning one month before and continuing for three months after conception.
    For reducing colon cancer risk: 400 mcg per day.
    For treating high levels of homocysteine in the blood:
        0.5-5 mg (milligrams)/day has been used, although 0.8-1 mg/day is appears to be more effective.
        In people with end-stage renal disease, high homocysteine levels may be more difficult to treat, and doses of 0.8-15 mg/day have been used. Other dosage plans such as 2.5-5 mg 3 times weekly have also been used. Doses higher than 15 mg daily do not seem to be more effective.
    For improving the response to medications for depression: 200-500 mcg daily has been used.
    For vitiligo: 5 mg is typically taken twice daily.
    For reduction of toxicity associated with methotrexate therapy for rheumatoid arthritis (RA) or psoriasis: 1 mg/day is probably enough, but up to 5 mg/day may be used.
    For preventing macular degeneration: folic acid 2.5 mg, vitamin B12 (cyanocobalamin) 1000 mcg, and vitamin B6 (pyridoxine) 50 mg daily.

The adequate intakes (AI) for infants are 65 mcg for infants 0-6 months and 80 mcg for infants 7-12 months of age. The recommended dietary allowances (RDAs) for folate in DFE, including both food folate and folic acid from fortified foods and supplements are: Children 1-3 years, 150 mcg; Children 4-8 years, 200 mcg; Children 9-13 years, 300 mcg; Adults over 13 years, 400 mcg; Pregnant women 600 mcg; and breast-feeding women, 500 mcg. The tolerable upper intake levels (UL) of folate are 300 mcg for children 1-3 years of age, 400 mcg for children 4-8 years, 600 mcg for children 9-13 years, 800 mcg for adolescents 14-18 years, and 1000 mcg for everyone over 18 years of age.


ေဖာလစ္အက္စစ္ (Folic Acid) 

ေဖာလစ္အက္ဆစ္သည္ ေရတြင္ အလြယ္တကူေပ်ာ္၀င္ႏိုင္ေသာ ဗီတာမင္ ဘီ အမ်ိဳးအစားျဖစ္ပါသည္။ ေဖာလစ္အက္ဆစ္သည္ အစာထဲတြင္ ပါ၀င္ေသာ ေဖာလိပ္ ( Folate) ကို ျဖိဳခြဲျခင္းမွ ရရွိေသာ ဓါတ္ျဖစ္ပါသည္။ ၁၉၉၈ ခုႏွစ္ေလာက္မွစ၍ ေဖာလစ္အက္ဆစ္ကို 

ေပါင္မုန္႔မ်ား၊ ကြတ္ကီးမုန္႕မ်ားႏွင့္ ဂ်ံဳႏွင့္ပက္သက္ေသာ အစားအစာအမ်ိဳးမ်ိဳးတို႔တြင္ ထည့္သြင္းလာသည္။ ေဖာလိပ္ဓါတ္ ၾကြယ္၀စြာပါ၀င္ေသာ အစားအစာမ်ားမွာ စိမ္းေသာ အရြက္မ်ား ၊ ငွက္ေပ်ာသီး ၊ ဖရဲသီး၊ ေရွာက္ခ်ိဳသီး၊ ပဲသီး၊ မိႈ အမ်ိဳးမ်ိဳး၊ အသား၊ လိေမၼာ္သီးႏွင့္ 

ခရမ္းခ်ဥ္သီးတို႔မွလည္း ရရွိပါသည္။  ေဖာလစ္အက္ဆစ္ကို ေသြးအားနည္းေရာဂါမ်ားတြင္ အဓိက ေပးေလ့ရွိပါသည္။ အထူးသျဖင့္ အဟာရမ်ား ျပည့္၀စြာ မစုုပ္ယူႏိုင္ေသာ လူနာမ်ားတြင္ ေပးရသည္။ ထုိ႔အျပင္ အသည္းေရာဂါရွင္မ်ား၊ အရက္သမားမ်ားႏွင့္ 

ေက်ာက္ကပ္ေရာဂါမ်ားတြင္လည္း အသံုးျပဳႏိုင္ပါသည္။ ကိုယ္၀န္ေဆာင္မိခင္မ်ားသည္ ကိုယ္၀န္ေဆာင္ေနစဥ္အတြင္းမွာ ေဖာလစ္အက္ဆစ္ကို သားေႏၶပ်က္က်ျခင္း၊ သားေႏၶသားဦးေႏွာက္ ခ်ိ္ဳ႕ယြင္းမႈေရာဂါ ကာကြယ္ျခင္းမွ ကာကြယ္ရန္ ေသာက္သံုးက်ပါသည္။ 

အခ်ိဳ႕သူမ်ားကလည္း ေဖာလစ္အက္ဆစ္ကို အူမၾကီးႏွင့္ သားအိမ္ေခါင္းကင္ဆာ ကာကြယ္ရန္ အသံုးျပဳၾကသည္။ ၄င္းကို ႏွလံုးေရာဂါ၊ ေလျဖတ္ေလငန္းေရာဂါ၊  စသည္တုိ႔ကို ကာကြယ္ရန္ အသံုးျပဳသည္။ မွတ္ဥာဏ္ခ်ိဳ႕တဲ့ျခင္း၊ အသက္ၾကီးသူမ်ားတြင္ ျဖစ္ေလ့ရွိေသာ 

နားေလးျခင္း၊ မ်က္စိရွိ macular ဆဲလ္မ်ား ပ်က္စီးျခင္းမွ ကာကြယ္ျခင္း၊ အရိုးပြျခင္း၊ အရိုးအားနည္းျခင္း၊ အိပ္၍မေပ်ာ္ျခင္း၊ စိတ္ဓါတ္က်ျခင္း၊ အာရံုေၾကာမ်ား ထံုက်ဥ္ကိုက္ခဲျခင္း၊ ၾကြက္သားနာျခင္း၊ ေခါင္းမူးျခင္း ႏွင့္ AIDS ေရာဂါမ်ားတြင္ အသံုးျပဳေလ့ရွိသည္။  

တစ္ခ်ိဳ႕လူမ်ားတြင္ သြားဖံုးပိုး၀င္ျခင္းမ်ားအတြက္ ေဖာလစ္အက္ဆစ္ကို လိမ္းၾကပါသည္။ မ်ားေသာအားျဖင့္ Folic acid ကို ဗီတာမင္ ဘီ မ်ားႏွင့္ တြဲ၍ အသံုးျပဳေလ့ ရွိပါသည္။ 

ေဖာလစ္အက္ဆစ္ကို ေက်ာက္ကပ္ေရာဂါသည္မ်ားတြင္ အသံုးျပဳသည္။ ေက်ာက္ကပ္ေရာဂါ အျပင္းအထန္ ခံစားေနသူမ်ားသည္ ဟိုမိုစစ္စတင္း (homocysteine) ပမာဏျမင့္တတ္ေလ့ရွိျပီး ေဖာလစ္အက္ဆစ္က ထုိပမာဏကုိ ေလ်ာ့က်ေစပါသည္။ Homocysteine 

ပမာဏ ျမင့္တတ္လာျခင္းသည္ ႏွလံုးေရာဂါႏွင့္ ေလျဖတ္ေရာဂါမ်ားကို ျဖစ္ေစႏုိင္ပါသည္။ Folic acid သည္ ေက်ာက္ကပ္ေရာဂါရွင္မ်ားတြင္ အသံုး၀င္ေသာ္လည္း ႏွလံုးေရာဂါႏွင့္ ပတ္သက္ေသာ ေရာဂါမ်ားကို မကာကြယ္ေပးႏိုင္ပါ။ Methotrexate ေဆး၏ 

ေဘးထြက္ဆိုးက်ိဳးျဖစ္ေသာ ေအာ့အန္ျခင္း၊ ပ်ိဳ႕အန္ျခင္းမ်ားကို သက္သာေစပါသည္။ ေမြးကင္းစကေလးမ်ားတြင္ ဦးေႏွာက္ႏွင့္ပတ္သက္ေသာ ဦးေႏွာက္ဆဲလ္ ခ်ိဳ႕ယြင္းမႈေရာဂါကိုလည္း လိုအပ္ေသာ ေဆးညႊန္းအတုိင္း ေသာက္ျခင္းျဖင့္ ကာကြယ္ေပးပါသည္။ 
Folic acid ကို အခ်ိဳ႕ဆရာ၀န္မ်ားက အသက္ၾကီးရင့္လာလ်င္ ျဖစ္တတ္ေသာ မ်က္စိမႈန္ျခင္း၊ မ်က္စိရွိ macular ဆဲလ္မ်ား ပ်က္စီးျခင္းေၾကာင့္ျဖစ္ေသာ အျမင္အာရံုက်ျခင္း၊ စိတ္ဓါတ္က်ျခင္း စသည္မ်ားတြင္လည္း အသံုးျပဳပါသည္။ စိတ္ဓါတ္က်ေရာဂါရွင္မ်ားကို Folic 

acid ႏွင့္ စိတ္က်ေရာဂါ ကာကြယ္ေဆးတြဲ၍ ေပးပါသည္။ ေသြးတုိးေရာဂါရွင္မ်ားတြင္လည္း ေသြးတုိးက်ေဆးႏွင့္တြဲဖက္၍ အသံုးျပဳၾကပါသည္။ သို႔ေသာ္ ၄င္း တစ္မ်ိဳးတည္းျဖင့္ ေသြးတိုးေရာဂါအတြက္ အသံုးမ၀င္ပါ။ သြားဖံုးႏွင့္ပတ္သက္ေသာ ေရာဂါအခ်ိဳ႕တြင္လည္း 

ေဖာလစ္အက္ဆစ္ကို လိမ္းျခင္းအားျဖင့္ သက္သာေပ်ာက္ကင္းေစပါသည္။ သမင္ျဖဴေရာဂါရွိသူမ်ား ေဖာလစ္အက္ဆစ္ကို ေန႔တိုင္းပံုမွန္ေသာက္သံုးပါက သမင္ျဖဴေရာဂါ လကၡဏာသက္သာေစပါသည္။


ေဖာလစ္အက္ဆစ္သည္ ေဘးထြက္ဆိုးက်ိဳးအလြန္နည္းပါးေသာ ေဆးျဖစ္ပါသည္။ ၁၀၀၀ mcg ပမာဏထက္ ေလ်ာ့နည္း၍ ေသာက္သုံးပါက ေဘးထြက္ဆိုးကိ်ဳးလံုး၀ မရွိပါ။ လိုအပ္သည္ထက္ ပိုေသာ ေဖာလစ္အက္ဆစ္ကို ေသာက္သံုးပါလ်င္ 

၀မ္းဗိုက္ႏွင့္ပတ္သက္ေသာေရာဂါမ်ား၊ ၀မ္းပ်က္၀မ္းေလွ်ာေရာဂါ၊ အစာအိမ္ေလပြျခင္း၊ အေရျပားဓါတ္မတည့္ျခင္း စသည္မ်ား ျဖစ္လာႏိုင္ပါသည္။ 

အထက္ပါ ဘာသာျပန္ခ်က္မ်ားသည္ သာမာန္လူမ်ားနားလည္ရန္ ဘာသာျပန္ထားျခင္းျဖစ္ျပီး ေဆးေလာကႏွင့္ပတ္သက္ေသာလူမ်ား အဂၤလိပ္လိုတြင္ ဖတ္ရႈႏုိင္ပါသည္။


General Inquiries

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